Clinical and Experimental Pancreatic Islet Transplantation to Striated Muscle: Establishment of a Vascular System Similar to that in Native Islets
نویسندگان
چکیده
Gustaf Christoffersson, Johanna Henriksnäs, Lars Johansson, Charlotte Rolny, Håkan Ahlström, José Caballero-Corbalan, Ralf Segersvärd, Johan Permert, Olle Korsgren, Per-Ola Carlsson, Mia Phillipson 1 Department of Medical Cell Biology, Box 571, SE-75123 Uppsala University, Uppsala, Sweden, Department of Oncology, Radiology and Clinical Immunology, Uppsala University, Uppsala, Sweden, Department of Genetics and Pathology, Uppsala University, Uppsala, Sweden Department for Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden, Department of Medical Sciences, Uppsala University, Uppsala, Sweden
منابع مشابه
Clinical and Experimental Pancreatic Islet Transplantation to Striated Muscle
OBJECTIVE Curing type 1 diabetes by transplanting pancreatic islets into the liver is associated with poor long-term outcome and graft failure at least partly due to inadequate graft revascularization. The aim of the current study was to evaluate striated muscle as a potential angiogenic site for islet transplantation. RESEARCH DESIGN AND METHODS The current study presents a new experimental ...
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Background: Islet transplantation could be an ideal alternative treatment to insulin therapy for type 1 diabetes Mellitus (T1DM). This clinical and experimental field requires a model that covers problems such as requiring a large number of functional and viable islets, the optimal transplantation site, and the prevention of islet dispersion. Hence, the methods of choice for isolation of functi...
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Objective(s): The use of a co-culture of islets with mesenchymal stromal cells (MSCs) is a promising therapy in islet transplantation to revert hyperglycaemia, but the resulting insulin-producing cells (IPCs) express low levels of pancreas endocrine developmental genes. This study aims to investigate the morphochronology of a co-culture of islets with MSCs from injured adult pancreata, and char...
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